Huntington Disease Versus Schizophrenia Essay Assignment paper
Huntington Disease Versus Schizophrenia Essay Assignment paper
Huntington’s disease (HD) is named after an American physician George Huntington in seventeen century, 1872 who contributed to a description of clinical features of the neurodegenerative disease. It is an autonomic dominant adult onset genetic disorder in which there is genetic mutation at the short arm of chromosome 4, whereby it consist of expansion of repeated CAG in the gene IT15 contribute to 36 or more CAG repeats on this gene as compare to healthy individuals that have only 11-35 CAG repeats (Corrêa, Xavier & Guimarães, 2006). HD’s triad of clinical presentations are cognitive decline, choreic movements and psychiatric manifestation.Huntington Disease Versus Schizophrenia Essay
The symptoms presented most often between ages 35 to 50. In HD only the brain is affected, other organs are spare. In comparison with other neurodegenerative disease such as Alzheimer and Parkinson’s disease, affected individual with HD are usually younger with less medical comorbidities (Huntington’’s Disease Society of America, 2014). The onset of HD seems to get earlier in succeeding generations, which is called “anticipation. ” The life span are around 10 to 20 years after onset of HD and finally the individual might passed away due to medical complications such as pneumonia or traumatic complication such as subdural hematoma, infections, malnutrition or cachexia due to dysphagia etc (Folstein, Leigh, Parhad & Folstein, 1986). The prodromal period of HD might presented with non-specific psychiatric syndromes leading to diagnosis confusion. Psychiatric manifestation such as schizophrenia-like psychosis, depression and personality disorder can precede, accompany or after the neuronal symptoms (Shiwach, 1994).Huntington Disease Versus Schizophrenia Essay
Huntington Disease Versus Schizophrenia Essay Assignment paper
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